Here is a collection of symtoms, signs and chracteristics of overmethylators and undermethylators from several sources. A few specific items are footnoted. I found the specific interesting. The consensus as to which is what is a bit fuzzy. Some things like depression show up on both lists according to different people. Many of the symptoms on BOTH lists are active b12 and folate deficiency symptoms. As far as response to b12 and folates are concerned, I'm just including what the sources say, not what I think. The ONLY thing they are all (sources) in full agreement on is response to SAM-e. high low style dresses for bridesmaid

UNDER METHYLATORS

Depression
High salivary flow
High tear flow
Never dry eyes
Good tolerance of cold
Poor tolerance of heat
Unexplained nausea
Hyperactivity
Frequent colds and flu
Phobias
Highly motivated
Hard driving personality
Poor pain tolerance
Joint pain
Joint swelling
Joint stiffness
Excess perspiration
Addictive tendencies
bipolar disorder
OCD
Schizophrenia
Insomnia
Muscle pains
Abundant or excess saliva in mouth
Obsessive compulsive
Slenderness
Do worse on b12 and folates (4)
Shopping/gambling disorders
Oppositional –defiant
Seasonal depression
Inhalant allergies
Frequent headaches,
Perfectionism
Competitiveness
Asthma
Vasomotor rhinitis
Allergic skin disorders
Pruritis
Excess stomach acid
Fatigue
High libido
Sparse body hair
Elevated absolute basophils
Extreme internal anxiety despite outwardly calm
Delusion thinking rather than hallucinations
Respond well to SAM-e, methionine, avoid folic acid (1)
Anorexia/bulimia
Low serotonin
Low dopamine
Low norepinephrine
Psychosis
Prone to hives
High motivation

OVER METHYLATORS

Elevated serotonin
Elevated dopamine
Elevated norepinephrine
High religiosity
High artistic/musical ability
Self injury
Auditory hallucinations
Absence of seasonal inhalant allergies
Frequent dry eyes
Multitude of chemical sensitivities
Multitude of food sensitivities
High anxiety evident to all
Low libido
Obsessions but not compulsions
Paranoia
Auditory hallucinations
Underachievement as child
Heavy body hair
Hyperactivity
Nervous legs
Grandiosity
Respond well to b12 but avoid SAM-e, inositol, methionine TMG and DMG (1)
Treatment revolves around folic acid, niacin, B12, and a high protein diet. (2)
Depression
Despair
Panic attacks
Upper body pain
Head pain
Nervous
Low salivary
Low tears
High pain tolerance
Low motivation
“space cadet”
Learning disabilities
Intolerance to SSRI drugs
Low perspiration